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KMID : 0525719990040010023
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Journal of Chitin and Chitosan
1999 Volume.4 No. 1 p.23 ~ p.30
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Control of Drug Release from Polymeric Matrices Coated with Poly ( DL - lactide ) - 2 . Effect of Coating Substance on the Drug Release in pH 7.4 Phosphate Buffer Solution -
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나재운/Nah JW
정영일/이동병/조종수/김성호/김성현/Jeong YI/Lee DB/Cho CS/Kim SH/Kim SH
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Abstract
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The polymeric matrices coated with poly(DL-lactide) were prepared using chitosan derivatives such as chitosan, chitosan hydrochloride, and sulfonated chitosan for application of drug deliver systems. The drug release study using prednisolone as a model drug was performed in the phosphate buffered solutions at PH 7.4. The release rate of drug was decreased according to the increased content of matrices. The release rate or predrusolone according to the kinds of polymeric matrices coated were decreased in the order of chitosan, sulfonated chitosan, and chitosan hydrochloride. Drug release rate of polymeric matrices coated with poly(DL-lactide) was not only two times slower than noncoated one, but also the burst effect of initial period of drug release was decreased In comparison with noncoated one. From these results it was expected that these formulations based on the chitosan derivative matrices coated with poly(DL-lactide) were acceptable drug delivery devices for a sustained-release dosage form of drug.
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